The Ras binding domain is found in many effectors and invariably binds to one of the switch regions, because these change conformation between the active and inactive forms.
42.
Chemerin is a 14 kDa protein secreted in an inactive form as prochemerin and is activated through cleavage of the C-terminus by inflammatory and coagulation serine proteases.
43.
Gemzar, which will be available by the end of the month, represents a new type of chemotherapy agent that is injected into the body in an inactive form.
44.
For example, in the active form, stem loop IIa is favored; in the inactive form a mutually exclusive interaction between the loop and a downstream sequence predominates.
45.
Another way that enzymes can exist in inactive forms and later be converted to active forms is by activating only when a cofactor, called a coenzyme, is bound.
46.
This autophosphorylation results in change of the structural conformation of the tyrosine kinase domain from an inactive form to an active one SRC tyrosine kinase are also activated by FGF signals.
47.
In its open, inactive form, the active site structure forms a loop while one subunit adopts an asymmetric open conformation and the other adopts a quasi-open conformation.
48.
The first 33 residues comprise the pre-pro ( inactive form ) region of the hormone, whereas the remaining 223 residues make up the mature form of the hormone.
49.
The laminin-like globular domain contains the active motif of endorepellin, and is unable to be cleaved by cells expressing mutant and inactive forms of the BMP-1 proteins.
50.
Methods have been developed to distinguish the proteolytic activity of different enzymes in biological samples and separate active proteases from their inactive forms, namely zymogen precursors and those proteases bound by inhibitors.
