Impaired proteasomal activity may underlie cognitive disorders such as the autism spectrum disorders, and muscle and nerve diseases such as inclusion body myopathy.
42.
The condition now called Desmin-related myofibrillar myopathy ( also called myofibrillar myopathy-1 ) was formerly called inclusion body myopathy 1 ( IBM1 ).
43.
In Pick's disease and corticobasal degeneration tau proteins are deposited in the form of inclusion bodies within swollen or " ballooned " neurons.
44.
Because they do not display inflammation as a primary symptom, they may in fact be similar, but different diseases to sporadic inclusion body myositis.
45.
There are two types : sporadic inclusion body myositis ( sIBM ), which is more common, and hereditary inclusion body myopathy ( hIBM ).
46.
There are two types : sporadic inclusion body myositis ( sIBM ), which is more common, and hereditary inclusion body myopathy ( hIBM ).
47.
April 2016 Novartis said that its breakthrough drug bimagrumab ( BYM338 ) failed a Phase IIb / III study for sporadic inclusion body myositis.
48.
However, not all proteins formed may be soluble in the cytoplasm, and incorrectly folded proteins formed in cytoplasm can form insoluble aggregates called inclusion bodies.
49.
Such infants may develop acute neonatal conjunctivitis within a few days of birth, and smears from their eyes reveal the presence of characteristic inclusion bodies.
50.
It has been suggested that inclusion bodies are dynamic structures formed by an unbalanced equilibrium between aggregated and soluble proteins of " Escherichia coli ".
