| 41. | Shugoshin also acts as a diffusible and mediates formation of kinetochore-microtubules during bipolar spindle assembly.
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| 42. | Plus ends that encounter kinetochores or sites of polarity become captured and no longer display growth or shrinkage.
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| 43. | Micrograph showing condensed chromosomes in blue, kinetochores in pink, and microtubules in green during metaphase of mitosis
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| 44. | During prometaphase, CDC20 and the SAC proteins concentrate at the kinetochores before attachment to the spindle assembly.
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| 45. | Thus, the kinetochore is essential for the chromosome segregation that is classically associated with mitosis and meiosis.
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| 46. | In addition, kinetochore localization of Bub1 early during G2 or prophase is another aspect of SAC functioning.
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| 47. | In late prometaphase, " kinetochore microtubules " begin to search for and attach to chromosomal kinetochores.
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| 48. | In late prometaphase, " kinetochore microtubules " begin to search for and attach to chromosomal kinetochores.
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| 49. | At the kinetochore, a variety of complexes have been shown to capture microtubule ( + )-ends.
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| 50. | These proteins keep the SAC activated until they are removed and the correct kinetochore-microtubule attachment is made.
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