The Rockefeller Foundation has a microbicide initiative, and the Gates Foundation recently set aside $ 25 million to help bring the right compound to market.
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A microbicide is at the top of health workers'wish list to protect the many women in poor countries whose husbands refuse to use condoms.
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"We're excited about the broad-spectrum nature, " said Dr . Penny Hitchcock, NIH's microbicide chief.
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International Development Secretary Clare Short said an effective microbicide _ in the form of gel or foam _ would empower women to protect themselves from AIDS.
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Although years of testing lie ahead, it's possible that a microbicide could be available by the end of the decade, she said.
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At the same time, an effective microbicide would not irritate the vagina or cervix; such damage could enhance the ability of HIV to infect cells.
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There is no such thing as a vaginal microbicide _ no cream, gel, foam or sponge that can protect against AIDS or other sexually transmitted diseases.
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But it still could take five years to find a safe, cheap and easy-to-use microbicide that would stop AIDS transmission, UNAIDS said.
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The Duet disposable diaphragm is made of dipped polyurethane, pre-filled with BufferGel ( BufferGel is currently in clinical trials as a spermicide and microbicide ).
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CAPRISA 004 is the name of a clinical trial testing a microbicide which was experimentally shown to be effective in reducing women's risk of contracting HIV.