| 41. | It is not an immunosuppressant, however, but rather it acts as a shield against microglia.
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| 42. | Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries.
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| 43. | The quinolinic acid produced in microglia is then released and stimulates NMDA receptors resulting in excitatory neurotoxiticity.
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| 44. | Molecular mediators are released by neurons, microglia, oligodendrocyte lineage cells, synaptic function and neural plasticity.
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| 45. | Accumulation of minor neuronal damage that occurs during normal aging can transform microglia into enlarged and activated cells.
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| 46. | Activated microglia making PGE 2 can then sensitize nociceptive neurons as manifested by their lowered threshold to pain.
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| 47. | Unlike the CB 1 receptor, in the brain, CB 2 receptors are found primarily on microglia.
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| 48. | TREM2 interacts with DAP12 in microglia to trigger phagocytosis of amyloid beta peptide and apoptotic neurons without inflammation.
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| 49. | Here he performed in-depth analysis on the reaction patterns of scavenger cells ( reactive microglia ).
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| 50. | He first explored the application of statins in suppressing the inflammatory events in microglia, astroglia and macrophages.
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