A deficiency of this enzyme is responsible for an inherited disorder of metabolism, Methylmalonyl-CoA mutase deficiency, which is one of the causes of methylmalonic acidemia ( also referred to as methylmalonic aciduria or MMA ).
42.
It has been proposed that high " MUT " expression ( thus high methylmalonyl-CoA mutase levels ) leads to lower cholesterol levels which increases resistance to bTB and affords an improved response to the BCG vaccine.
43.
A carboxyl group is attached to AIR by N5-CAIR synthetase to form N5-Carboxyaminoimidazole ribonucleotide ( N5-CAIR ), which is then converted to Carboxyamino-imidazole ribonucleotide ( CAIR ) with enzyme N5-CAIR mutase.
44.
(" R " )-Methylmalonyl-CoA is converted to succinyl-CoA, an intermediate in the tricarboxylic acid cycle, by methylmalonyl-CoA mutase, an enzyme requiring cobalamin to catalyze the carbon-carbon bond migration.
45.
Helices are present all around the beta barrels; in particular, a C-terminal helical domain splits off from the barrel to interact with the barrel of a neighboring subunit, in a " helix swapping " motif ( see phosphoenolpyruvate mutase ).
46.
Either mutations to the gene " MUT " ( encodes methylmalonyl-CoA mutase ), or " MMAA " ( encodes a chaperone protein of methylmalonyl-CoA mutase, " MMAA " protein ) can lead to methylmalonyl acidemia.
47.
Either mutations to the gene " MUT " ( encodes methylmalonyl-CoA mutase ), or " MMAA " ( encodes a chaperone protein of methylmalonyl-CoA mutase, " MMAA " protein ) can lead to methylmalonyl acidemia.
48.
Zebrafish embryos exposed to hypoxia decreased expression of genes involved in the citric acid cycle including, succinate dehydrogenase, malate dehydrogenase, and citrate synthase, and increased expression of genes involved in glycolysis such as phosphoglycerate mutase, enolase, aldolase, and lactate dehydrogenase.
49.
Its synthesis and breakdown are, therefore, a way around a step of glycolysis, with the net expense of one ATP per molecule of 2, 3-BPG generated as the high-energy carboxylic acid-phosphate mixed anhydride bond is cleaved by bisphosphoglycerate mutase.
50.
Other enzymes also belong to this family including carboxyvinyl-carboxyphosphonate phosphorylmutase ( ) which catalyses the conversion of 1-carboxyvinyl carboxyphosphonate to 3-( hydrohydroxyphosphoryl ) pyruvate carbon dioxide, and phosphoenolpyruvate mutase ( ), which is involved in the biosynthesis of phosphinothricin tripeptide antibiotics.
