Increases in antibody-antigen binding strength have been achieved by introducing mutations into the complementarity determining regions ( CDR ), using techniques such as chain-shuffling, randomization of complementarity-determining regions and antibodies with mutations within the variable regions induced by error-prone E . coli mutator strains and site-specific mutagenesis.
42.
But when the food supply varies, even though the mutators lose relative to an " A " or " B " non-mutator, they may lose less than them over the long run because, for example, an " A " type loses a lot when ? is low.
43.
As well as describing the fragments as gibs, the word may be used as a verb, and killing a game character in this manner is to " gib " them . " Gib ", and the related term " frag ", are most commonly used in multiplayer mod or mutator in which a hit on an opponent results in instantaneous " gibbing ".
44.
Yet there is evidence that more than 80 % of the somatic mutations found in mutator phenotype human colorectal tumors occur before the onset of terminal clonal expansion . " Similarly, Vogelstein et al . pointed out that more than half of somatic mutations identified in tumors occurred in a pre-neoplastic phase ( in a field defect ), during growth of apparently normal cells.
45.
The mutator method is most often used in object-oriented programming, in keeping with the principle of class are made private to hide and protect them from other code, and can only be modified by a public member function ( the mutator method ), which takes the desired new value as a parameter, optionally validates it, and modifies the private member variable.
46.
The mutator method is most often used in object-oriented programming, in keeping with the principle of class are made private to hide and protect them from other code, and can only be modified by a public member function ( the mutator method ), which takes the desired new value as a parameter, optionally validates it, and modifies the private member variable.
47.
Yet there is evidence that more than 80 % of the somatic mutations found in mutator phenotype human colorectal tumors occur before the onset of terminal clonal expansion & " Similarly, Vogelstein et al . also indicated that more than half of somatic mutations identified in tumors occurred in a pre-neoplastic phase ( in a field defect ), during growth of apparently normal cells.
48.
Yet there is evidence that more than 80 % of the somatic mutations found in mutator phenotype human colorectal tumors occur before the onset of terminal clonal expansion . " Similarly, Vogelstein et al . point out that more than half of somatic mutations identified in tumors occurred in a pre-neoplastic phase ( in a field defect ), during growth of apparently normal cells.
49.
However, it does not always do so, namely in case of very short functions, where the function body is smaller than the size of a function call ( at the caller, including argument and return value handling ), such as trivial accessor methods or mutator methods ( getters and setters ); or for a function that is only used in one place, in which case it is not duplicated.
