| 41. | An asymmetric variant of this reaction utilizes acyl nucleophile equivalents generated by N-heterocyclic carbene catalysis.
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| 42. | Serine and cysteine proteases use different amino acid functional groups ( alcohol or thiol ) as a nucleophile.
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| 43. | In order to activate that nucleophile, they orient an acidic and basic residue in a catalytic triad.
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| 44. | The azide anion behaves as a nucleophile; it undergoes nucleophilic substitution for both aliphatic and aromatic systems.
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| 45. | This reaction is similar to nucleophilic aliphatic substitution where the reactant is a nucleophile rather than an electrophile.
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| 46. | In electrophilic amination, the amine as the nucleophile react with another the organic compound as the electrophile.
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| 47. | This is likely in cases when the allyl compound is unhindered, and a strong nucleophile is used.
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| 48. | The iodide leaving group in methyl iodide may cause side reactions, as it is a powerful nucleophile.
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| 49. | Once a nucleophile attacks and a tetrahedral intermediate is formed, the energetically favorable resonance effect is lost.
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| 50. | The benzoate anion acts as a nucleophile again to displace iodide through a neighboring-group participation mechanism.
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