This then condenses with the arginine side chain to yield glucosepane in nucleophilic addition-elimination reactions of the nitrogens of arginine and the electrophilic carbonyls on the ring, eliminating two waters.
42.
If the pK a were not perturbed downward, the lysine residue would remain protonated as an ammonium cation, making it unreactive for the nucleophilic addition necessary to form the Schiff base.
43.
Rate of polar nucleophilic addition reaction versus 1, 3-dipolar cycloaddition in decalin and in DMSO ( doi : 10.1016 / S0040-4039 ( 00 ) 70991-9)
44.
In this case the nucleophilic addition reaction happens at the face where the hydrogen ( the small group ) is, producing the ( R, R )-isomer as the major product.
45.
Nucleophilic addition of a carbanion or another nucleophile to the double bond of an alpha, beta unsaturated carbonyl compound can proceed via the Michael reaction, which belongs to the larger class of conjugate additions.
46.
The polar reaction, N-cyclo " pen " tenyl pyrrolidine nucleophilic addition to the diazo compound, proceeds 1, 500 times faster in polar DMSO than in non-polar decalin.
47.
A Knoevenagel condensation is a nucleophilic addition of an active hydrogen compound to a carbonyl group followed by a dehydration reaction in which a molecule of water is eliminated ( hence " conjugated enone ).
48.
It is also considered an addition-elimination reaction : nucleophilic addition of the-NH 2 group to the C = O carbonyl group, followed by the removal of a H 2 O molecule.
49.
This nucleophilic addition results in the formation of citroyl " CoA [ " O 2 CCH 2 CH ( CO 2 " ) CH 2 C ( = O ) " SCoA ].
50.
The reaction mechanism undergoes three major steps, the first one being the protonation of the oxygen on the carbonyl in the ?-diketone, which then undergoes a nucleophilic addition reaction with the aniline.
