In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation.
42.
One of the three mutations shifts the population in favor of the higher order oligomerization state in solution as shown by both size exclusion chromatography and native gel electrophoresis.
43.
In all probability, the oligomerization status is connected with the chaperone activity : aggregates of large oligomers have high chaperone activity, whereas dimers have no chaperone activity.
44.
This nuclear import process, mediated by karyopherins, acts on assembled VP1 pentamers in complex with VP2 or VP3; oligomerization to form capsids occurs in the nucleus.
45.
Increasing concentrations of cholesterol ( and other sterols ) cause a change in this domain's oligomerization state, which makes it more susceptible to destruction by the proteosome.
46.
Mitochondrial SLC25A transporters can detect these low levels and stimulate OPA1 oligomerization, leading to tightening of the cristae, enhanced assembly of ATP synthase, and increased ATP production.
47.
It was previously known as " nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3 " ( NOD3 ) and CLR16.2.
48.
IL-1RAcP is a second receptor subunit of IL-1RI . By forming a receptor heterodimer with IL-1RI facilitates signalization due to oligomerization of TIR domains of these proteins.
49.
The muations occur in a cysteine-string domain, which is required for membrane targeting / binding, palmitoylation and oligomerization of the encoded protein cysteine-string protein alpha ( CSP? ).
50.
It is believed that the intracellular transport of the nascent protein depends, to some extent, on the oligomerization of Env precursors, which allows hydrophobic sequences to be buried inside the protein structure.
