Multiple other measures, including particle sizes, small LDL particle concentrations, large total and HDL particle concentrations, along with estimations of insulin resistance pattern and standard cholesterol lipid measurements ( for comparison of the plasma data with the estimation methods discussed above ) are also routinely provided.
42.
When the particle concentration is so low that it is possible to follow an individual particle it is called Particle tracking velocimetry, while Laser speckle velocimetry is used for cases where the particle concentration is so high that it is difficult to observe individual particles in an image.
43.
When the particle concentration is so low that it is possible to follow an individual particle it is called Particle tracking velocimetry, while Laser speckle velocimetry is used for cases where the particle concentration is so high that it is difficult to observe individual particles in an image.
44.
The manufacturers have not yet generated and submitted data to show that the drugs improved outcomes of cardiovascular disease; it is assumed that lowering LDL-particle concentrations would reduce cardiovascular disease event rates, as has occurred in all the statin clinical trials, pending ongoing further clinical trials of the PCSK9 inhibitor outcomes.
45.
Using NMR, as pioneered by researcher Jim Otvos and the North Carolina State University academic research spin-off company LipoScience, the total LDL particle concentrations, in nmol / L plasma, are typically subdivided by percentiles referenced to the 5, 382 men and women, not on any lipid medications, who are participating in the MESA trial.
46.
This formula provides an approximation with fair accuracy for most people, assuming the blood was drawn after fasting for about 14 hours or longer, but does not reveal the actual LDL particle concentration because the percentage of fat molecules within the LDL particles which are cholesterol varies, as much as 8 : 1 variation.
