The transcript begins, at the beginning of R, is capped, and proceeds through U5 and the rest of the provirus, usually terminating by the addition of a poly A tract just after the R sequence in the 3'LTR.
42.
In 1999 Barbulescu, " et al . " showed that, of ten HERV-K proviruses cloned, eight were unique to humans, while one was shared with chimpanzees and bonobos, and one with chimpanzees, bonobos and gorillas.
43.
:Satoshi Mizutani and Howard Martin Temin jointly discovered that the Rous sarcoma virus particle contained the enzyme reverse transcriptase, and Mizutani was solely responsible for the original conception and design of the novel experiment that confirmed Temin's " provirus hypothesis ".
44.
In a study to be released Friday, virologists at Thomas Jefferson University in Philadelphia said that patients with the HIV provirus _ the genetic component of the AIDS virus _ might still be able to transmit the virus to others if they fail to practice safe sex.
45.
However, retroviruses function differently, as their RNA is reverse-transcribed into DNA, which is integrated into the host cell's genome ( when it becomes a provirus ), and then undergoes the usual transcription and translational processes to express the genes carried by the virus.
46.
Now, all you have to do is administer a little systemwide " signal " into the bloodstream that will trigger this provirus out of latency; cells everywhere in the body would suddenly activate viral replication . . . talk ) 16 : 36, 18 August 2009 ( UTC)
47.
As such, we are interested in the host cell's mechanisms to silence such gene expressions to find out firstly, how the host cell manages provirus transcription to eliminate the deleterious effects of retroviruses; and secondly, how can we ensure stable and long term expression of retrovirus-mediated gene transfer.
48.
The number of deaminations in the preferred regions varies from one to many, possibly dependent on the time of exposure to APOBEC3G . Some HIV-1 proviruses with APOBEC3G-mediated mutation have been shown to thrive because they carry too few mutations at APOBEC3G hotspots or because recombination between a lethally APOBEC3G-restricted provirus and a viable provirus has occurred.
49.
The number of deaminations in the preferred regions varies from one to many, possibly dependent on the time of exposure to APOBEC3G . Some HIV-1 proviruses with APOBEC3G-mediated mutation have been shown to thrive because they carry too few mutations at APOBEC3G hotspots or because recombination between a lethally APOBEC3G-restricted provirus and a viable provirus has occurred.
50.
The number of deaminations in the preferred regions varies from one to many, possibly dependent on the time of exposure to APOBEC3G . Some HIV-1 proviruses with APOBEC3G-mediated mutation have been shown to thrive because they carry too few mutations at APOBEC3G hotspots or because recombination between a lethally APOBEC3G-restricted provirus and a viable provirus has occurred.
