The " intraclass correlation " is commonly used to quantify the degree to which individuals with a fixed degree of relatedness ( e . g . full siblings ) resemble each other in terms of a quantitative trait ( see heritability ).
42.
The assumption is that the marker associates at high frequency with the gene or quantitative trait locus ( QTL ) of interest, due to genetic linkage ( close proximity, on the chromosome, of the marker locus and the disease resistance-determining locus ).
43.
With a former PhD student Lon Cardon ( who went on to discover linkage for dyslexia on chromosome 6 and to work in the human International HapMap Project ) and Stacey Cherny, Fulker worked on methods for linkage and association analysis of quantitative traits.
44.
He believed that natural selection and Mendelian genetics were compatible, and referred to the theoretical work of Sewall Wright, R . A . Fisher, and J . B . S . Haldane, which proved that quantitative traits and natural selection were compatible with Mendelism.
45.
Interestingly, two studies using integrative genomic approaches to investigate genetic modifiers of collagen deposition or intrinsic aerobic running capacity ( ARC ) have mapped " PDLIM3 " to respective quantitative trait loci, suggesting that ALP may be involved in molecular networks related to these cardiac phenomena.
46.
In classical genetics, if genes A and B are mutated, and each mutation by itself produces a unique phenotype but the two mutations together show the same phenotype as the gene A mutation, then gene A is epistatic and gene B is Quantitative Trait Loci ( QTL ) and polygenic inheritance.
47.
Rosyara U . R ., J . L . Gonzalez-Hernandez, K . D . Glover, K . R . Gedye and J . M . Stein . 2009 . Family-based mapping of quantitative trait loci in plant breeding populations with resistance to Fusarium head blight in wheat as an illustration Theoretical Applied Genetics 118 : 1617-1631
