| 41. | Some severe diseases can depend on the presence or absence of some enzymes related to the sialic acid metabolism.
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| 42. | This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids.
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| 43. | The synthesis starts in the cytosol, where N-acetylmannosamine 6 phosphate and phosphoenolpyruvate give rise to sialic acid.
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| 44. | This prevents most Siglecs from binding to other cells as mammalian cells are covered in sialic acid-containing glycans.
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| 45. | The letter G refers to ganglioside, and M is for monosialic acid as it has one sialic acid only.
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| 46. | Typically, mature human glycoproteins only contain three mannose residues buried under sequential modification by GlcNAc, galactose and sialic acid.
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| 47. | The enzyme uses a mannose derivative as a substrate, inserting three carbons from pyruvate into the resulting sialic acid structure.
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| 48. | Sialic acid can " hide " mannose antigens on the surface of host cells or bacteria from mannose-binding lectin.
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| 49. | Administration of estrogen to castrated mice leads to a dose-dependent reduction of the sialic acid content of the vagina.
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| 50. | Free sialic acid possibly can help the bacterium to recognize that it has reached a vertebrate environment suitable for its colonization.
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