Sequence families are often determined by sequence clustering, and structural genomics projects aim to produce a set of representative structures to cover the sequence space of possible non-redundant sequences.
42.
So the new effort, known as structural genomics, aims to determine the three-dimensional structures of thousands upon thousands of proteins, much as the genome project determined gene sequences en masse.
43.
Structural alignments are especially useful in analyzing data from structural genomics and proteomics efforts, and they can be used as comparison points to evaluate alignments produced by purely sequence-based bioinformatics methods.
44.
As opposed to traditional structural biology, the determination of a protein structure through a structural genomics effort often ( but not always ) comes before anything is known regarding the protein function.
45.
-- Midwest Center for Structural Genomics ( Argonne National Laboratory, Northwestern University, Washington University School of Medicine, University College London, UT Southwestern Medical Center at Dallas, University of Toronto, University of Virginia)
46.
One advantage of structural genomics, such as the Protein Structure Initiative, is that the scientific community gets immediate access to new structures, as well as to reagents such as clones and protein.
47.
These methods are also being used for the successful annotation of structural genomics proteins, i . e . for the discovery of the function of gene products whose function is currently unknown.
48.
*A project was proposed by two teams from National Center of Scientific Research ( Centre Nationale de la recherche scientifique ou CNRS ), Laboratory of yeast structural genomics from the University of Orsay.
49.
Membrane proteins, by contrast, are difficult to crystallize and are underrepresented in the PDB . Structural genomics initiatives have attempted to remedy these deficiencies by systematically solving representative structures of major fold classes.
50.
The striking parallels between structural genomics and genomics raise questions about whether there will be the competition and petty sniping that accompanied the efforts by Celera and the Human Genome Project until their recent truce.
