A more recent study showed that the administration of synephrine by continuous intravenous infusion, at the rate of 4 mg / minute, significantly increased mean arterial and diastolic pressure and heart rate were unaltered .;
42.
Bayer AG's Neo-Synephrine nose drops may pose a risk to patients during ear, nose, and throat surgery, and its use should be carefully evaluated, New York's health commissioner said.
43.
Bayer Corp .'s Neo-synephrine and American Home Products'Dristan were each off more than 10 percent while Procter & Gamble Co .'s Sinex and Vicks each fell more than 6 percent.
44.
Using cats and dogs, Tainter and Seidenfeld observed that neither d-nor l-synephrine caused any changes in the tone of normal bronchi, " in situ ", even at " maximum " doses.
45.
Experiments on strips of rabbit duodenum showed that l-synephrine caused a modest reduction in contractions at a concentration of 1 : 17000, but that the effects of the d-and d, l-forms were much weaker.
46.
Although clearly indicating a selectivity of synephrine for ? 1 receptors, its potency at this receptor sub-class is still relatively low, in comparison with that of phenylephrine ( pD 2 at ? 1 = 6.32 ).
47.
Synephrine constrictions were also antagonized by BRL-15, 572, but not by SB-216, 641 ( used here as a selective 5-HT 1B antagonist ), or by propranolol ( a common ? antagonist ).
48.
The potency, expressed in terms of pD 2 of synephrine in these species was as follows : rat : 4.38; hamster : 5.32; guinea pig : 4.31; human : 4.94.
49.
Thus, replacement of the " N "-methyl group in synephrine with a hydrogen atom gives " N "-methyltyramine; replacement of the synephrine phenolic 4-OH group by a H gives halostachine.
50.
Thus, replacement of the " N "-methyl group in synephrine with a hydrogen atom gives " N "-methyltyramine; replacement of the synephrine phenolic 4-OH group by a H gives halostachine.
