The tertiary amine contained within the quinuclidine can act as a nucleophile that attacks the most electrophilic carbon of the ketene to promote the formation of ?-lactams.
42.
In the proposed reaction mechanism the base first converts the acid chloride to the ketene, the organocatalyst then introduces chirality through its quininoid tertiary amine, forming a ketene adduct.
43.
Imipramine, a tertiary amine, affects numerous neurotransmitter systems known to be involved in the etiology of depression, anxiety, ADHD, enuresis and numerous other mental and physical conditions.
44.
Chiral tertiary amine catalysts are employed for enantioselective MBH reactions . ?-ICD, a cinchona alkaloid derivative, is famous among the quinidine framework-based catalysts in this sense.
45.
In the Hofmann elimination, treatment of a quaternary ammonium iodide salt with silver oxide produces hydroxide ion, which acts as a base and eliminates the tertiary amine to give an alkene.
46.
For this reason, use of chlorinated solvents, particularly dichloromethane, may be inadvisable when a tertiary amine is present in a reaction mixture and heating and / or extended reaction times are required.
47.
In 2013, trimethylamine was identified as a potent full agonist of human TAAR5, a trace amine-associated receptor that is expressed in the olfactory epithelium and functions as an olfactory receptor for tertiary amines.
48.
On the other hand, it catalyzes the oxidation of alkanes to tertiary alcohols, amides to t-butyldioxyamides, and tertiary amines to ?-( t-butyldioxyamides ) using tert-butyl hydroperoxide.
49.
Even pyridines, which are considerably less nucleophilic than typical tertiary amines, are reported to react with dichloromethane at room temperature over a period of several days to weeks to give bis ( pyridinium ) methane salts.
50.
Bis-tris methane is an organic tertiary amine with labile protons having a pKa of 6.46 at 25 �C . It is an effective buffer between the pH 5.8 and 7.3.
