The therapeutic index of cardiac glycosides is H " 2; this is quite narrow, indicating that only a small dose is needed for the compound to be toxic.
42.
This effect of protein binding is most significant with drugs that are highly protein-bound ( > 95 % ) and have a low therapeutic index, such as warfarin.
43.
In clinical human trials with increasing dosages, vanoxerine has shown to have a highly favourable therapeutic index, showing no side effects at concentrations much higher than the therapeutic dose.
44.
The protective index is similar to the therapeutic index, but concerns toxicity ( TD 50 ) rather than lethality ( ); thus, the protective index is a smaller ratio.
45.
Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life ( " t " 1 / 2 = 120 days ), making dosing difficult.
46.
Future direction in the development of ADCs also include the development of site-specific conjugation ( TDCs ) to further improve stability and therapeutic index and ? emitting immunoconjugates and antibody-conjugated nanoparticles.
47.
Nevertheless, the therapeutic index is still useful as it can be considered an upper bound for the protective index, and the former also has the advantages of objectivity and easier comprehension.
48.
This interaction is particularly dangerous when the drug in question has a low therapeutic index, so that a small increase in blood concentration can be the difference between therapeutic effect and toxicity.
49.
There are tighter requirements for drugs with a narrow therapeutic index and / or saturable metabolism & ndash; thus no generic products exist on the Australian market for digoxin or phenytoin for instance.
50.
A drug with a thin therapeutic range, or small therapeutic index, will be determined unfit for a sustained release mechanism in partial fear of dose dumping which can prove fatal at the conditions mentioned.
