Also banned are any other growth factor affecting muscle, tendon or ligament protein synthesis / degradation, vascularization, energy utilization, regenerative capacity or fiber type switching; and other substances with similar chemical structure or similar biological effects.
42.
In the case of using a so-called perforator flap, a reliable vascularization and the possibility of sensory ( re ) innervation can be combined with less donor-site morbidity and limited loss of function in the donor area.
43.
Based on the lack of fusion between elements of the basicarnium and a high degree of vascularization of the bone surface, which suggests the animal was undergoing a rapid growth stage when it died, the holotype skull of " Russellosaurus coheni " is believed to have come from a subadult individual.
44.
Although the issue has not been extensively studied in a controlled fashion, GCCLs have been noted to contain significantly elevated levels of VEGF . However, in one study where a giant-cell carcinoma tumor that had been completely excised was sectioned and examined, no qualitative or quantitative abnormalities in tissue vascularization were noted.
45.
The prefrontal cortex, which plays an important role in explicit memory retrieval, was also found to have decreased neural activation in patients scanned during the episode of PTA . Researchers noted that the damage was related to vascularization and neural functionality, but not to structural injury, suggesting that the resolution of PTA is dependent on functional changes.
46.
Donor site morbidity, lack of donor tissue, and inadequate vascularization all limit the ability of doctors to adequately treat VML . The field of muscle tissue engineering attempts to address this problem through the design of a functional muscle construct that can be used to treat the damaged muscle instead of harvesting an autologous muscle flap from somewhere else on the patient s body.
47.
CYP4F2 along with CYP4A22, CYP4A11, and CYP4F3 and CYP2U1 also metabolize arachidonic acid to 20-Hydroxyeicosatetraenoic acid ( 20-HETE ) by an Omega oxidation reaction with the predominant 20-HETE-synthesizing enzymes in humans being CYP4F2 followed by CYP4A11; 20-HETE regulates blood flow, vascularization, blood pressure, and kidney tubule absorption of ions in rodents and possibly humans.
48.
CYP4A22 was once considered, along with CYP4A11, CYP4F2, and CYP4F3, as active in metabolizing arachidonic acid to 20-hydroxyeicosatetraenoic acid ( 20-HETE ) by an omega oxidation reaction with the predominant 20-HETE-synthesizing enzymes in humans being CYP4F2 followed by CYP4A11; 20-HETE regulates blood flow, vascularization, blood pressure, and kidney tubule absorption of ions in rodents and possibly humans.
49.
Since the regulation of vascularization in the mature retina involves a balance between endogenous positive growth factors, such as vascular endothelial growth factor ( VEGF ) and inhibitors of angiogenesis, such as pigment epithelium-derived factor ( PEDF ), rAAV-mediated expression of PEDF, angiostatin, and the soluble VEGF receptor sFlt-1, which are all antiangiogenic proteins, have been shown to reduce aberrant vessel formation in animal models.
50.
CYP4F3A and / or CYP43B also omega oxidize arachidonic acid to 20-Hydroxyeicosatetraenoic acid ( 20-HETE ) as well as epoxyeicosatrienoic acids ( EETs ) to 20-hydroxy-EETs . 20-HETE regulates blood flow, vascularization, blood pressure, and kidney tubule absorption of ions in rodents and possibly humans; it has also been proposed to be involved in regulating the growth of various types of human cancers ( see 20-Hydroxyeicosatetraenoic acid # cancer ).
