Intravenous administration of a developmental drug can provide valuable information on the fundamental pharmacokinetic parameters of volume of distribution ( " V " ) and clearance ( " CL " ).
42.
Drug delivery systems may also be able to prevent tissue damage through regulated drug release; reduce drug clearance rates; or lower the volume of distribution and reduce the effect on non-target tissue.
43.
The blood volume would only be slightly less without legs anyway ( maybe 90-95 % ), and the blood volume makes a difference only to the initial volume of distribution of the alcohol.
44.
The half life of tolcapone is 2 3 hours, volume of distribution ( V d ) being 0.3 L / kg ( 21 L in average 70 kg person ) and bioavailability about 60 %.
45.
Since the dose is a set physical mass, the only method of administering it to mimic the initial volume of drug at that time is to have a small, or even vanishingly small volume of distribution.
46.
They differ in both pharmacokinetics ( absorption factor, half-life, volume of distribution, clearance ) and pharmacodynamics ( for example the capacity of mineralocorticoid activity : retention of sodium ( Na + ) and albumin.
47.
Pharmacokinetics describes the effect of the body on the chemical ( e . g . half-life and volume of distribution ), and pharmacodynamics describes the chemical's effect on the body ( desired or toxic ).
48.
The volume of distribution is 0.7-1 L / kg after a single dose, 4.7-6 L / kg after steady-state concentrations are achieved and up to 11.1 L / kg after prolonged dosing.
49.
The "'initial volume of distribution "'is a pharmacological term used to quantify the distribution of a drug throughout the body relatively soon after oral or intravenous dosing of a drug and prior to the drug reaching a steady state equilibrium.
50.
Due to the good permeability of blonanserin, the volume of distribution in the central nervous system is greater than that in the periphery ( Vd central = 9500 L, Vd periphery = 8650 L ) although it is slower to absorb into the central compartment.
