Other related compounds were being investigated clinically at this time, including biguanide derivatives.
2.
"' Phenformin "'is an antidiabetic drug from the biguanide class.
3.
It is a polymer or oligomer where biguanide functional groups are connected by hexyl hydrocarbon chains, with varying chain lengths.
4.
In 1929, Slotta and Tschesche discovered its sugar-lowering action in rabbits, finding it the most potent biguanide analog they studied.
5.
More patients in the Polyhexamethylene biguanide group healed in the 6-month period when compared with the controls-97 % v . 89 %.
6.
"' Buformin "'( 1-butylbiguanide ) is an oral antidiabetic drug of the biguanide class, chemically related to metformin and phenformin.
7.
A retrospective analysis of wound cleanser clinical efficacy and cost-effectiveness focussed on Polyhexamethylene biguanide solution, Ringer s solution or saline in 112 venous leg ulcer patients.
8.
The study group received the Polyhexamethylene biguanide solution ( n = 59 ) and the control group received either Ringer s solution or saline ( n = 53 ).
9.
Later, working at Laboratoires Aron in Paris, he was prompted by Garcia's report to reinvestigate the blood sugar-lowering activity of metformin and several biguanide analogs.
10.
Phenformin, another biguanide, was withdrawn from the market because of an increased risk of lactic acidosis ( rate of 40-64 per 100, 000 patient-years ).
