| 1. | Bradykinin plays a critical role in all forms of hereditary angioedema.
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| 2. | Dampening or inhibiting bradykinin has been shown to relieve HAE symptoms.
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| 3. | Its effect on bradykinin is responsible for the dry cough side effect.
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| 4. | HMWK in turn is cleaved by the enzyme kallikrein to produce bradykinin.
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| 5. | Sunburn causes an inflammation process, including production of prostanoids and bradykinin.
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| 6. | They also can produce bradykinin with a closely related effect.
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| 7. | Some patients develop angioedema due to increased bradykinin levels.
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| 8. | Various mechanisms that interfere with bradykinin production or degradation can lead to angioedema.
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| 9. | An association with bradykinin has been proposed in the case of hereditary angioedema.
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| 10. | Blocking bradykinin receptors in the lumbar region of the spinal cord reversed persistent pain.
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