| 1. | Maleic anhydride is a dienophile in the Diels-Alder reaction.
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| 2. | Norbornadiene is also a useful dienophile in Diels-Alder reactions.
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| 3. | The HOMO of the dienophile reacts with the LUMO of the diene.
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| 4. | The most important consideration in choice of dienophile is its relative orbital energies.
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| 5. | Imines are electron-poor, and thus usually function as the dienophile.
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| 6. | The catalyst encapsulates the diene and dienophile, increasing the effective concentration of reactants.
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| 7. | As such, the highly strained trans-cyclooctene is used as a reactive dienophile.
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| 8. | It is an excellent prochiral dienophile.
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| 9. | What type of substitution pattern would it encourage if I say, used pyrrole as the dienophile?
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| 10. | However, when the dienophile substituents are endo, there is considerable orbital overlap with the diene.
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