| 1. | Androstenedione can be converted to testosterone, estrone, and estradiol.
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| 2. | Estrone and estradiol are also produced in the placenta during pregnancy.
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| 3. | Estrone is a major estrogen that is normally found in women.
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| 4. | Estrone sulfate is usually the major form of estrogen in women.
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| 5. | It has estrogenic activity similarly to estrone and 4-hydroxyestrone.
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| 6. | Estrone was discovered and isolated by German chemist Adolf Butenandt.
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| 7. | The transformation of estrone sulfate to estrone is catalyzed by estrone sulfatase.
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| 8. | The transformation of estrone sulfate to estrone is catalyzed by estrone sulfatase.
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| 9. | The transformation of estrone sulfate to estrone is catalyzed by estrone sulfatase.
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| 10. | As such, estrone is the main estrogen elevated in the condition.
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