| 1. | Nitrofurantoin and its metabolites are excreted mainly by the kidneys.
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| 2. | Nitrofurantoin and the quinolone antibiotics are mutually antagonistic " in vitro ".
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| 3. | However, a retrospective chart review may suggest nitrofurantoin is not contraindicated in this population.
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| 4. | Urinary tract infections can be treated specifically with nitrofurantoin, even in cases of vancomycin resistance.
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| 5. | Chronic pulmonary reactions caused by nitrofurantoin include diffuse interstitial pneumonitis, pulmonary fibrosis, or both.
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| 6. | Resistance to nitrofurantoin may be chromosomal or plasmid-mediated and involves inhibition of nitrofuran reductase.
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| 7. | It is not known which of the actions of nitrofurantoin is primarily responsible for its bactericidal activity.
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| 8. | For the same reason, nitrofurantoin should not be given to pregnant women after 38 weeks of pregnancy.
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| 9. | At the concentrations achieved in urine ( > 100 ?g / ml ), nitrofurantoin is a bactericide.
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| 10. | Nitrofurantoin should not be used in patients with a creatinine clearance of 60 ml / min or less.
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