| 1. | The phagosome then combines with a lysosome to create a phagolysosome.
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| 2. | The fusion of lysosomes with the phagosome creates a phagolysosome . 3.
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| 3. | In addition, production of the diterpene isotuberculosinol prevents maturation of the phagosome.
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| 4. | Membrane fusion of the phagosome and lysosome is regulated by Rab 5 protein.
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| 5. | ATG13 is an autophagy factor required for phagosome formation.
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| 6. | Then, the bacteria is phagocytosized by the host cell and enveloped by a phagosome.
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| 7. | They grow and multiply inside the phagosome.
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| 8. | Upon release from the phagosome, the toxin has reduced activity in the more basic cytosol.
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| 9. | The bacteria also carry the " UreC " gene, which prevents acidification of the phagosome.
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| 10. | After LLO lyses the phagosome, the bacterium escapes into the cytosol, where it can grow intracellularly.
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