| 1. | These then begin meiosis to form the oocyte within the primordial follicle.
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| 2. | DNA double-strand breaks accumulate with age in humans and mice in primordial follicles.
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| 3. | As women age, double-strand breaks accumulate in the DNA of their primordial follicles.
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| 4. | This can take many months in vivo and involves primordial follicle growth and differentiation.
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| 5. | Primordial follicles are immature primary oocytes surrounded by a single layer of granulosa cells.
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| 6. | Babies are born with 1-2 million primordial follicles, and by puberty have around 300, 000.
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| 7. | They showed that as women age, double-strand breaks accumulate in the DNA of their primordial follicles.
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| 8. | Primordial follicles contain oocytes that are at an intermediate ( prophase I ) stage of meiosis.
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| 9. | Female infertility by chemotherapy appears to be secondary to premature ovarian failure by loss of primordial follicles.
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| 10. | (a ) The maturation of a follicle is shown in a clockwise direction proceeding from the primordial follicles.
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