| 1. | Prophylaxis with mefloquine was compared to prophylaxis with atovaquone-proguanil.
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| 2. | Proguanil displays synergism when used in combination with the antimalarial atovaquone.
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| 3. | It is proposed that drugs such as proguanil act to disrupt retinoid homeostasis.
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| 4. | Atovaquone-proguanil is an effective alternative in patients unable to tolerate chloroquine.
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| 5. | This mechanism of action differs from when proguanil was used as a singular agent.
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| 6. | A standard tablet of Malarone contains 100 mg of proguanil hydrochloride and 250 mg of atovaquone.
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| 7. | A pediatric tablet contains 25 mg of proguanil hydrochloride and 62.5 mg of atovaquone.
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| 8. | Atovaquone / proguanil has been commercially available from GlaxoSmithKline since 2000, and its patent expired in 2013.
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| 9. | Proguanil, via its metabolite cycloguanil, functions as a dihydrofolate reductase inhibitor, halting parasitic deoxythymidilate synthesis.
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| 10. | The combination atovaquone-proguanil may be used in those patients who are unable to take chloroquine for whatever reason.
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