| 1. | The molecular weight of prothrombin is approximately 72, 000 Da.
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| 2. | Most people with the prothrombin mutation ( G20210A ) never develop thrombosis.
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| 3. | Manipulation of prothrombin is central to the mode of action of most anticoagulants.
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| 4. | This can lead to an increase in prothrombin time.
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| 5. | The most common problem is the factor V Leiden and prothrombin G20210A mutation.
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| 6. | By having too much prothrombin, it increases the chances the blood clotting.
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| 7. | Males typically have larger clotting factors ( vitamin K, prothrombin and platelets ).
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| 8. | Factor Xa ( in the presence of factor V ) activates prothrombin into thrombin.
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| 9. | For example, it is needed to carboxylate specific glutamic acid residues on prothrombin.
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| 10. | Prothrombin complex concentrate, cryoprecipitate and fresh frozen plasma are commonly used coagulation factor products.
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