| 1. | Nicotine has a similar pharmacophore to acetylcholine, especially when protonated.
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| 2. | At any lower pH, the fraction of protonated nicotine is greater.
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| 3. | Glu217 is protonated to donate a proton to N1 of the substrate.
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| 4. | When dissociated, the diisopropylamide anion can become protonated to form Diisopropylamine.
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| 5. | The salt bridge formed is between the deprotonated Asp70 and protonated His31.
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| 6. | C 6 H 7 +, which is protonated benzene.
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| 7. | The amine is protonated at physiological pH condition, triggering better uptake.
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| 8. | An interesting case I think, is when acetic anhydride gets protonated.
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| 9. | Protonated polyamines, particularly macrocyclic ones, can bind anions.
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| 10. | In the example, the ether oxygen is reversibly protonated.
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