| 1. | Additionally, patients may present with erythema nodosum, cutaneous pustular vasculitis, and lesions similar to pyoderma gangrenosum.
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| 2. | A significant number of episodes revolve around autoimmune disorders, ranging from Pyoderma gangrenosum to Paraneoplastic cerebellar degeneration.
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| 3. | Finally, smaller series have detailed an association with pyoderma gangrenosum, bacterial and viral infections, and occasionally, malignancies.
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| 4. | One hallmark of pyoderma gangrenosum is pathergy, which is the appearance of new lesions at sites of trauma.
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| 5. | Pyoderma gangrenosum is variably expressed, which means that it is not always present in all individuals with the disease.
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| 6. | For instance, ulcerative colitis, rheumatoid arthritis, and multiple myeloma ( MM ) have all been associated with pyoderma gangrenosum.
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| 7. | The inflammation and ulceration that occurs as a result of pathergy in pyoderma gangrenosum often responds to systemic steroid therapy.
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| 8. | In 1998, after suffering for five years from a rare immune disorder, pyoderma gangrenosum, Rock Brynner took thalidomide and went into remission.
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| 9. | Also in support of an immune etiology is the finding that at least half of all pyoderma gangrenosum patients suffer from immune-mediated diseases.
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| 10. | There is currently a phase III trial for the use of the IL-1B modulating agent gevokizumab in treating the ulcers of pyoderma gangrenosum.
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