| 1. | A less negative resting membrane potential is made, leading to increased irritability.
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| 2. | Voltage-sensitive sodium channels become persistently active at the resting membrane potential.
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| 3. | This potassium conductance eventually drops and the cell returns to its resting membrane potential.
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| 4. | Lower potassium levels in the extracellular space cause hyperpolarization of the resting membrane potential.
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| 5. | In the heart, hypokalemia causes hyperpolarization in the myocytes'resting membrane potential.
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| 6. | This may allow Kv3.4-KCNE3 channels to contribute to setting resting membrane potential.
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| 7. | However, the removal of Na + does not alter the resting membrane potential of the cell.
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| 8. | In general, LTS cannot be triggered by depolarization of the neuron from the resting membrane potential.
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| 9. | They, along with the " leak " channels, establish the resting membrane potential of the cell.
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| 10. | Consequently, this shift in their activation profile results in channels that open closer to the resting membrane potential.
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