| 1. | Via this mechanism, tumor suppressor genes can be deactivated, leading to cancer.
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| 2. | Mutations in tumor suppressor genes are common in Type II endometrial cancer.
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| 3. | The first tumor suppressor gene validating this hypothesis was that encoding p53.
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| 4. | If a mutation inactivates a tumor-suppressor gene, cell multiplication can continue unchecked.
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| 5. | Other factors are mutations in or total loss of tumor suppressor genes.
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| 6. | Typically, there is hypermethylation of tumor suppressor genes and hypomethylation of oncogenes.
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| 7. | As with the SDHC and SDHD genes, SDHB is a tumor suppressor gene.
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| 8. | Because of these properties, the p53 gene is known as a tumor-suppressor gene.
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| 9. | Scientists know just how certain oncogenes and suppressor genes are damaged.
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| 10. | Genetic abnormalities frequently occur in a tumor-suppressor gene called caspase 8.
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