Therefore, alcohol consumption may increase the production of uroporphyrinogen, exacerbating symptoms in individuals with porphyria cutanea tarda.
2.
This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains.
3.
This is an autosomal recessive inborn error of metabolism that results from the markedly deficient activity of uroporphyrinogen III synthase.
4.
Additionally, exposure to chlorinated cyclic hydrocarbons can lead to a deficiency in the activity of uroporphyrinogen decarboxylase, causing the buildup of excess uroporphyrinogen.
5.
Additionally, exposure to chlorinated cyclic hydrocarbons can lead to a deficiency in the activity of uroporphyrinogen decarboxylase, causing the buildup of excess uroporphyrinogen.
6.
Hydroxymethyl bilane is a major anabolic product, from the biosynthetic reaction of porphobilinogen ( PBG ) and uroporphyrinogen I synthase ( known as porphobilinogen deaminase ).
7.
In the metabolism of porphyrin, it is formed from uroporphyrinogen III by the enzyme uroporphyrinogen III decarboxylase, and it is converted into protoporphyrinogen IX by coproporphyrinogen III oxidase.
8.
In the metabolism of porphyrin, it is formed from uroporphyrinogen III by the enzyme uroporphyrinogen III decarboxylase, and it is converted into protoporphyrinogen IX by coproporphyrinogen III oxidase.
9.
Siroheme is synthesized from the central tetrapyrrole molecule uroporphyrinogen III, which forms the first branch-point of tetrapyrrole biosynthetic pathway, the other branch being the heme / chlorophyll branch.
10.
Four PBGs are then combined through deamination into hydroxymethyl bilane ( HMB ), which is hydrolysed to form the circular tetrapyrrole uroporphyrinogen III . This molecule undergoes a number of further modifications.
