aconitase वाक्य
उदाहरण वाक्य
मोबाइल
- Finally, aconitase is thought to be associated with diabetes . ) and genetic diabetes, lower aconitase activity was found to decrease the rates of metabolic reactions involving citrate, pyruvate, and malate.
- For example, in the presence of low iron concentrations, aconitase functions as an enzyme while at high iron concentration, aconitase functions as an iron-responsive element-binding protein ( IREBP ).
- For example, in the presence of low iron concentrations, aconitase functions as an enzyme while at high iron concentration, aconitase functions as an iron-responsive element-binding protein ( IREBP ).
- Mutant IRE-BPs, in which any or all of the three Cys residues involved in Fe-S formation are replaced by serine, have no aconitase activity, but retain RNA-binding properties.
- These include oxidation of iron-containing proteins such as ribonucleotide reductase and aconitase, activation of the soluble guanylate cyclase, ADP ribosylation of proteins, protein sulfhydryl group nitrosylation, and iron regulatory factor activation.
- A proposed mechanism for this connection is that decreased Fe-S activity in aconitase and succinate dehydrogenase is correlated with excess iron concentration in the mitochondria and insufficient iron in the cytoplasm, disrupting iron homeostasis.
- When this happens, the aconitase is converted to IRPF1, a translation repressor or mRNA stabilizer that represses the formation of iron-binding proteins and favours formation of proteins that can get iron from the cell's reservations
- The most sensitive targets of NO are aconitase, an enzyme that catalyzes the isomerization of citrate to isocitrate in the citric acid cycle, and cytochrome oxidase, the last enzyme in the respiratory electron transport chain of mitochondria.
- The iron-responsive element-binding protein ( IRE-BP ) and 3-isopropylmalate dehydratase ( ?-isopropylmalate isomerase; ), an enzyme catalysing the second step in the biosynthesis of leucine, are known aconitase homologues.
- Expression of IRE-BP in cultured cells has revealed that the protein functions either as an active aconitase, when cells are iron-replete, or as an active RNA-binding protein, when cells are iron-depleted.
- In the prefrontal cortex, HK1 putatively forms a protein complex with EAAT2, Na + / K + ATPase, and aconitase, which functions to remove glutamate from the perisynaptic space and maintain low basal levels in the synaptic cleft.
- The high efficiency of superoxide dismutase seems necessary : even at the subnanomolar concentrations achieved by the high concentrations of SOD within cells, superoxide inactivates the citric acid cycle enzyme aconitase, can poison energy metabolism, and releases potentially toxic iron.
- In other words, when there is high iron in the cell, the iron itself causes the cell to produce more iron storage molecules . ( The IRE-BP is an aconitase; for a schematic drawing of the shape change, see here ).
- Examples of the application of this technique in biochemistry include the study of reactions catalyzed by nucleoside diphosphohexose-4, 6-dehydratases, the aconitase-catalyzed elimination of water from citrate, and various reactions catalyzed by coenzyme B 12-dependent enzymes, among others.
- I expect wikipedia to have information on everything, there are certainly some not so notable listings such as the aconitase enzyme page, which I imagine was easy to get " notability " for, but will be read far fewer times than this page will . & # 151; ( talk)
- Figure legend : blue color = reaction steps of the citric acid cycle; brown color = reaction steps of the malate aspartate shuttle; green color = enzymes overexpressed in tumors . 1 = glutaminase, 2 = GOT, 3 = ?-ketoglutarate dehydrogenase, 4 = succinate dehydrogenase, 5 = fumarase, 6 = malate dehydrogenase, 7a = cytosolic malic enzyme, 7b = mitochondrial malic enzyme, 8 = citrate synthase, 9 = aconitase, 10 = lactate dehydrogenase
- अधिक वाक्य: 1 2
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