binding surface वाक्य
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- Three-dimensional structures of examples of all the soluble, cytoplasmic complexes of the PTS were solved by G . Marius Clore using multidimensional NMR spectroscopy, and led to significant insights into how signal transduction proteins recognize multiple, structurally dissimilar partners by generating similar binding surfaces from completely different structural elements, making use of large binding surfaces with intrinsic redundancy, and exploiting side chain conformational plasticity.
- Clore is known for the development of three-and four-dimensional NMR spectroscopy, the use of residual dipolar couplings for structure determination, the development of simulated annealing and restrained molecular dynamics for three-dimensional protein and nucleic acid structure determination, the solution NMR structure determination of large protein complexes, the development of the combined use of NMR and small-angle X-ray scattering in solution structure determination, and the analysis and characterization of protein dynamics by NMR . He is one of the main authors of the very widely used XPLOR-NIH NMR structure determination program, which evolved from the program X-PLOR developed by Axel Brunger and originally based on the program phosphotransferase system ( PTS ) led to significant insights into how signal transduction proteins recognize multiple, structurally dissimilar partners by generating similar binding surfaces from completely different structural elements and exploiting side chain conformational plasticity.
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