complement cascade वाक्य
उदाहरण वाक्य
मोबाइल
- Mannan-binding lectin, also called mannose-binding protein, is a protein belonging to the collectin family that is produced by the liver and can initiate the complement cascade by binding to pathogen surfaces.
- By inhibiting the complement cascade at this point, the normal, disease-preventing functions of proximal complement system are largely preserved, while the properties of C5 that promote inflammation and cell destruction are impeded.
- The subsequent complement cascade catalyzed by C3-convertase results in creating a membrane attack complex, which causes lysis of the pathogen as well as altered-self in the context of apoptotic and necrotic cells.
- When someone has a heart attack, for instance, the lack of oxygen in heart cells causes necrosis in heart cells : Dying heart cells spill their contents in the extracellular environment, which triggers the complement cascade.
- Besides surrounding foreign bodies in the bloodstream, complement proteins can also bind to one another in a " complement cascade, " forming a structure that punctures an invader _ and sometimes neighboring healthy cells as well.
- P . S . I am more interested in the possibility of harnessing the protein b12 to a C . V . F . homologue to hunt varmints through the complement cascade-system, a fantastic product of my idiocy.
- As part of the innate immune system, elements of the complement cascade can be found in species earlier than vertebrates; most recently in the protostome horseshoe crab species, putting the origins of the system back further than was previously thought.
- When the paratope of Ig class " gamma " ( IgG ) binds its matching epitope, IgG's Fc region conformationally shifts and can host a complement protein, initiating the complement cascade that terminates by punching a hole in a cell membrane.
- This means that if C3b is bound to a " self " cell, the presence of sialic acid and the binding of factor H will prevent the complement cascade from activating; if C3b is bound to a bacterium, factor B will bind and the cascade will be set off as normal.
- Since C3 convertases cleave C3 to produce C3b which can then form an additional C3 convertase through the alternative pathway, this is a potential mechanism of signal amplification in the complement cascade resulting in the deposition of large numbers of C3b molecules on the surface of activating particles, enabling opsonisation and acute local inflammation.
- Mutations in three of the proteins in the complement cascade have been identified in patients with atypical HUS . Several chemotherapeutic drugs have also been shown to cause damage to the epithelial layer by reducing the ability for the cells to produce prostacyclin, ultimately resulting in chemotherapy-associated HUS, or C-HUS.
- Sachs envisions " the ideal transgenic pig " as an animal with a variety of human genes working together against rejection : Genes to prevent human antibodies from binding to the pig organ, genes to inhibit the complement cascade and block endothelial-cell activation, genes that cause receptors to vital human growth factors and hormones to sprout on the pig cells.
- The graft is given a break from humoral rejection when the complement cascade is interrupted, circulating antibodies are removed, or their function is changed, or there is a change in the expression of surface antigens on the graft . This allows the xenograft to up-regulate and express protective genes, which aid in resistance to injury, such as heme oxygenase-1 ( an enzyme that catalyzes the degradation of heme ).
- In brief, the crucial role of C1q in the pathway is its importance as the first protein to start the complement cascade ( which ends in the destruction of the invading bacteria or virus ), and its ability to link the two important arms of the immune system the innate immune system : a broad defence system; and the adaptive immune system : the strong immune response capable of remembering previous infections, allowing fast response against recurrent infections, meaning that people with a normal immune system don't continually catch the same cold or same strain of flu repeatedly.
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