corepressor वाक्य
उदाहरण वाक्य
मोबाइल
- This protein is also a transcriptional corepressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases.
- In prokaryotes, the term corepressor is used to denote the activating " trp " operon when its corepressor tryptophan is bound to it.
- In prokaryotes, the term corepressor is used to denote the activating " trp " operon when its corepressor tryptophan is bound to it.
- Only when a corepressor is bound to the lac repressor will the binding site be free for RNA polymerase to carry out transcription of the lac genes.
- Mutations of MEF2B enhance its transcriptional activity due to either a disruption with its corepressor CABIN1 or causing the gene to become insensitive to inhibitory signaling events.
- In place of the missing H12, Rev-erb? displays a hydrophobic interface that binds the corepressor N-CoR, making it a potent transcriptional repressor.
- However, when the ratio of the corepressor PAX2, the expression of HER2 is upregulated in the presence of tamoxifen, leading to tamoxifen-resistant breast cancer.
- As a part of BCL6 corepressor complex, MTA3 regulates BCL6-dependent repression of target genes, including PRDM1, and modulates the differentiation of B-cells.
- This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via transcriptional corepressor SMRT . Multiple alternatively spliced transcript variants encoding several isoforms have been found for this gene.
- The encoded protein is a subunit of the histone deacetylase-dependent SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including splice variants encoding different isoforms have been characterized.
- It interacts with the paired amphipathic alpha-helix 2 ( PAH2 ) domain of mSin3, a transcriptional repressor domain that is attached to transcription repressor proteins such as the mSin3A corepressor.
- The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ / zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis.
- The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others.
- SAP130 is a subunit of the histone deacetylase ( see HDAC1; MIM 601241 )-dependent SIN3A ( MIM 607776 ) corepressor complex ( Fleischer et al ., 2003 ) . [ supplied by OMIM]
- SDS3 is a subunit of the histone deacetylase ( see HDAC1; MIM 601241 )-dependent SIN3A ( MIM 607776 ) corepressor complex ( Fleischer et al ., 2003 ) . [ supplied by OMIM]
- LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor ( NR ) box.
- Recruitment of corepressors, generally occurring in the absence of ligand, depends on a critical conformation of the receptor AF-2 domain, as well as upon nuclear receptor box-like helical motifs in the corepressor.
- The function of PPARs is modified by the precise shape of their ligand-binding domain ( see below ) induced by ligand binding and by a number of corepressor proteins, the presence of which can stimulate or inhibit receptor function, respectively.
- The MTA3-NuRD complex represses Snail, a master regulator of epithelial-to-mesenchymal transition ( EMT ), and BCL6-corepressor target genes The MTA3-NuRD complex interacts with GATA3 to regulate the expression of GATA3 downstream targets.
- These enzymes catalyze the hydrolysis of acetylated lysine residues restoring the positive charge to histone proteins and hence the tie between histone and DNA . PELP-1 can act as a transcriptional corepressor for transcription factors in the nuclear receptor family such as glucocorticoid receptors.
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