demethylation वाक्य
उदाहरण वाक्य
मोबाइल
- Sulpiride, along with clozapine, has been found to activate DNA demethylation in the brain.
- Current antipsychotic drugs, like clozapine and sulpiride, have been shown to also induce demethylation.
- Maeder et al . has constructed a ZF-TET1 protein for use in DNA demethylation.
- After N-demethylation of oxymorphone, noroxymorphone is further glucuronidated to noroxymorphone-3-glucuronide.
- Histones H3 and H4 can also be manipulated through demethylation using histone lysine demethylase ( KDM ).
- The demethylation occurs when JmjC utilizes multiple cofactors to hydroxylate the methyl group, thereby removing it.
- Further processing of aristolactam I by O-demethylation results in aristolactam Ia, the primary metabolite.
- Codeine is metabolised by O-and N-demethylation in the liver to morphine and norcodeine.
- The demethylation of sarcosine catalyzed by sarcosine dehydrogenase can proceed with or without the presence of tetrahydrofolate.
- They prevent the demethylation of the H3K4 histone protein and open up that part of the chromatin.
- Loxapine may be metabolized by " N "-demethylation to amoxapine, a tetracyclic antidepressant.
- Oxymorphone is also a minor metabolite of oxycodone, which is formed by CYP2D6-mediated O-demethylation.
- O-demethylation of DXM to DXO contributes to at least 80 % of the DXO formed during DXM metabolism.
- Additional demethylation reactions occur in tumor cells, releasing formaldehyde in situ before the drug is excreted in the urine.
- Nicodicodeine is metabolised in the liver by demethylation to produce 6-nicotinoyldihydromorphine, and subsequently further metabolised to dihydromorphine.
- Tetrahydrofolate here serves as a 1-carbon acceptor during the demethylation process ( See figure 3 for mechanism ).
- It has also been suggested that members of the DNA damage repair GADD45 family may contribute to this demethylation process.
- Under anaerobic condition and without tetrahydrofolate, however, a free formaldehyde is formed after the N-demethylation of sarcosine.
- This demethylation process is the first step in the highly sought-after demethylation pathway of DMSP degradation in marine bacteria.
- This demethylation process is the first step in the highly sought-after demethylation pathway of DMSP degradation in marine bacteria.
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