erythroblast वाक्य
उदाहरण वाक्य
मोबाइल
- During this process ICAM-4 binds to VLA-4, an erythroblast binding site, on adjacent erythroblasts and to ?v integrins on macrophages to help stabilise the erythroblastic islands.
- The mRNA from human erythroblasts is ~ 1.4 kilobases long and the transcription start site in erythroid cells has been mapped to 1050 base pairs 5'of the start codon.
- Critical functions in the developing red blood cell ( erythroblast ) include the establishment of the erythroid cytoskeleton, enzymes that mediate heme biosynthesis, and polypeptide chains that constitute the hemoglobin tetramer.
- Subsequent differentiation stages ( proerythroblast to orthochromatic erythroblast ) involve a decrease in cell size and eventual expulsion of the nucleus, and are likely dependent upon EpoR signaling only for their survival.
- These results suggest that Fli-1 overexpression in erythroblasts alters their responsiveness to Epo and triggers abnormal proliferation by switching the signaling event ( s ) associated with terminal differentiation to proliferation.
- "' Sideroblasts "'( "-blast " ) are atypical, abnormal nucleated erythroblasts ( precursors to mature red blood cells ) with granules of iron accumulated in the mitochondria surrounding the nucleus.
- Mice that over expression of NR2F6 in their bone marrow cells have a block at the pro-erythroblast stage of blood cell development both in the bone marrow and in the spleen of animals that have excessive expression of NR2F6.
- At the IBPC, he studied the structure of giant RNA of the messenger type in cells differentiation ( avian erythroblasts ) and formulated the hypothesis of the existence of pre-messengers pre-mRNA by analogy to pre-rRNA.
- In this form of AML, levels of erythroblasts can reach up to 94.8 % of all nucleated cells in the bone marrow, and the immature forms of the erythroblasts, the proerythroblasts and basophilic erythroblasts, are more commonly found.
- In this form of AML, levels of erythroblasts can reach up to 94.8 % of all nucleated cells in the bone marrow, and the immature forms of the erythroblasts, the proerythroblasts and basophilic erythroblasts, are more commonly found.
- In this form of AML, levels of erythroblasts can reach up to 94.8 % of all nucleated cells in the bone marrow, and the immature forms of the erythroblasts, the proerythroblasts and basophilic erythroblasts, are more commonly found.
- Cell number in a colony is important because pro-erythroblast stage is also Epo-responsive ( expresses Epo receptor ), but the proliferative capacity of these cells is not as high, thus yielding a colony with fewer than 8 cells.
- One study noted that in control leukemic groups with general AML, immature erythroblasts accounted for 8 % of all erythroid cells, but in a group with pure erythroid leukemia, this number was a minimum of 40 %, and ranged up to 83 %.
- Early erythroid progenitors are found at a quite low frequency relative to later stages of erythroid differentiation, such as the pro-erythroblast and the basophilic erythroblast stages which can be detected by flowcytometry directly ex-vivo ( Socolovsky et al . 2001 PMID 11719363 ).
- Early erythroid progenitors are found at a quite low frequency relative to later stages of erythroid differentiation, such as the pro-erythroblast and the basophilic erythroblast stages which can be detected by flowcytometry directly ex-vivo ( Socolovsky et al . 2001 PMID 11719363 ).
- It is unknown whether EpoR signaling plays a " permissive " ( i . e . induces only survival ) or an " instructive " ( i . e . upregulates erythroid markers to " lock " progenitors to a predetermined differentiation path ) role in early, multipotent progenitors in order to produce sufficient erythroblast numbers.
- Furthermore, unlike for the pro-erythroblast and later stages of erythroid development, no truly reliable and unique positive flow-cytometric markers exist, though it is possible to use negative exclusion markers to deplete a cell population of other precursors and differentiated cells by cell sorting, thus greatly enriching it for the CFU-e activity ( Prospective isolation and global gene expression analysis of the erythrocyte colony-forming unit, Terszowski G . et al.
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