hemolysin वाक्य
उदाहरण वाक्य
मोबाइल
- Uropathogenic " E . coli " use P fimbriae ( pyelonephritis-associated alpha-and beta-hemolysins, which cause lysis of urinary tract cells.
- But the fact that hemolysins ( produced by pathogenic microorganisms during infections ) are combined with other virulence factors may threaten a human's life to a greater extent.
- The diarrhetic syndromes observed in patients are thought to stem from the three toxins : hemolysin BL ( Hbl ), nonhemolytic enterotoxin ( Nhe ) and cytotoxin K ( CytK ).
- Many hemolysins are pore-forming toxins ( PFT ), which are able to cause the lysis of erythrocytes, leukocytes, and platelets by producing pores on the cytoplasmic membrane.
- The heptamer of ?-hemolysin from " Staphylococcus aureus " has a mushroom-like shape and measures up to 100 ?in diameter and 100 ?in height.
- Early industrial research into this method was based on a technique called'Exonuclease sequencing', where the readout of electrical signals occurring at nucleotides passing by alpha-hemolysin pores covalently bound with cyclodextrin.
- In this case, it has been proven that alpha-hemolysin takes part in inducing necrotic pulmonary injury by the use of the NLRP3 inflammasome, which is responsible for inflammatory processes and of pyroptosis.
- Premature activation of leukocytes and inhibition of phagocytosis and chemotaxis by alpha-hemolysin, if they occur " in vivo ", would greatly enhance the survival of an E . coli attack.
- Another interesting point is that pretreatment of leukocytes with doses of alpha-hemolysin at which nearly 80 % of the cells survived decreased the ability of the cells to phagocytize bacteria and particles and to undergo chemotaxis.
- Protein nanopore sequencing utilizes membrane protein complexes such as "-Hemolysin, MspA ( Mycobacterium Smegmatis Porin A ) or CssG, which show great promise given their ability to distinguish between individual and groups of nucleotides.
- In 1993, he and Dan Branton initiated a research collaboration with John Kasianowitz at NIST to explore this possibility with the hemolysin channel, and in 1996 published the first paper demonstrating that nanopore sequencing may be feasible.
- Mark Akeson joined the research effort in 1997, and in 1999 published a paper showing that the hemolysin channel, now referred to as a nanopore, could distinguish between purine and pyrimidine bases in single RNA molecules.
- In particular, the problem is that when an exonuclease hydrolyzes the phosphodiester bonds between nucleotides in DNA, the subsequently released nucleotide is not necessarily guaranteed to directly move in to, say, a nearby alpha-hemolysin nanopore.
- While modification of large protein channels using mutagenesis are generally considered out of the scope of " synthetic " channels, the demarcation is not sharp, as supramolecular or covalent bonding of cyclodextrins to alpha-hemolysin demonstrates.
- The regulation of the production of hemolysin in " S . aureus " ( expression of hemolysin ) is now possible due to " in-vitro " mutations that are related to serine / threonine kinase and phosphatase.
- The regulation of the production of hemolysin in " S . aureus " ( expression of hemolysin ) is now possible due to " in-vitro " mutations that are related to serine / threonine kinase and phosphatase.
- The researchers found that a subset which encoded the gene for the cryptic serine protease SepA, previously described in " Shigella ", and lacking the transcriptional regulator of hemolysin expression, " rmoA " were associated with virulence.
- The passage of RNA or single-stranded DNA molecules through the membrane-embedded alpha-hemolysin channel ( 1.5 nm diameter ), for example, causes a ~ 90 % blockage of the current ( measured at 1 M KCl solution ).
- Not only are the erythrocytes affected by hemolysins, but there are also some effects among other blood cells, such as leucocytes ( white blood cells ) . " Escherichia coli " hemolysin is potentially cytotoxic to monocytes, lymphocytes and macrophages, leading them to autolysis and death.
- Not only are the erythrocytes affected by hemolysins, but there are also some effects among other blood cells, such as leucocytes ( white blood cells ) . " Escherichia coli " hemolysin is potentially cytotoxic to monocytes, lymphocytes and macrophages, leading them to autolysis and death.
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