hemophilia b वाक्य
उदाहरण वाक्य
मोबाइल
- Lusher and colleagues reported on the peculiar side effect profile ( i . e ., anaphylaxis, nephrotic syndrome ) of recombinant factor IX in patients with hemophilia B.
- Meanwhile, in St . Petersburg, Alexei is confined to his bed suffering from severe bruising to his leg caused by Hemophilia B, a disease that prevents proper blood clotting.
- Defective calcium binding to coagulation factor IX contributes to the development of hemophilia B . Individuals afflicted with this hereditary disease tend to develop hemorrhages, potentially leading to life-threatening conditions.
- Monday's news comes on the heels of even more encouraging results from a gene therapy trial for hemophilia B, the less common form which affects 1 in 50, 000 men.
- About 5, 000 Americans suffer from hemophilia B . They produce insufficient levels of a clotting protein known as Factor IX . As a result, blood leaks into their joints.
- Bayer AG's American subsidiary signed a deal Friday with the U . S . biotechnology firm Avigen for worldwide rights to distribute its gene therapy treatment for hemophilia B, Coagulin-B.
- In the hemophilia B trial the vector carries the correct version of the human gene for Factor IX, one of the cascade of proteins involved in making the blood clot.
- Cohen said protein injections to curb hemophilia A represent a market of $ 1 . 6 billion in the United States, more than four times the market for hemophilia B.
- A gene therapy treatment for hemophilia B might be of great benefit, he said, and would need to be weighed against the risks, including that of inadvertently modifying the human germline.
- Deficiency of this protein causes hemophilia B . It was discovered in 1952 after a young boy named Stephen Christmas was found to be lacking this exact factor, leading to hemophilia.
- A gene therapy treatment for hemophilia B might be of great benefit, he said, and would need to be weighed against the risks, including that of inadvertently modifying the human germ line.
- The trial, conducted by Avigen of Alameda, Calif ., is designed to insert a corrective gene into the liver of patients with hemophilia B, the less common of two forms of hemophilia.
- In January 2007, the company announced it would acquire Syntonix Pharmaceuticals for up to $ 120 million, gaining Syntonix's lead product for hemophilia B as well as the technology for developing inhalable treatments.
- The results, which produced a blood-clotting protein without adverse side effects, were reported in research connected with hemophilia B, which affects about 5, 000 Americans, or 20 percent of all hemophiliacs in America.
- In 2009 genetic analysis determined specifically that he suffered from hemophilia B . He had to be careful not to injure himself because he lacked factor IX, one of the proteins necessary for blood-clotting.
- Hemophilia B is a good target for gene therapy because the level of Factor IX in the bloodstream needs to be raised and sustained at only 1 percent of normal for patients to benefit.
- The trial, conducted by Avigen Inc . of Alameda, Calif ., is designed to insert a corrective gene into the liver of patients with hemophilia B, the less common of two forms of hemophilia.
- Calcium-binding EGF-like domains ( cbEGF-like domains ) play a seminal role in diseases such as the Marfan syndrome or the X-chromosome linked hemorrhagic disorder hemophilia B and are among the most abundant extracellular calcium-binding domains.
- But Nagle said hemophilia B is so rare _ only 150 cases are diagnosed annually _ that seven subjects are probably representative of those in the general population who suffer from this rare bleeding disorder.
- The cause of hemophilia B is decreased activity or deficiency of blood coagulation factor IX . Point mutations resulting in decreased affinity of factor IX to calcium are thought to be implicated in this bleeding disorder.
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