host factor वाक्य
उदाहरण वाक्य
मोबाइल
- "It confirms what people have thought _ that there are obviously host factors that are very critical to a person's history of HIV, " said Dr . Keith Hoots, a professor of pediatrics at the UT Medical School in Houston.
- Carrington said the new finding probably has no immediate usefulness for HIV-infected patients _ for instance, in determining which ones should be treated more aggressively because they carry the AIDS-promoting gene _ because there are probably many " host factors " involved in HIV infection.
- Enhancement of virus release on the other hand involves the neutralization of a cellular host factor, BST-2 ( also known as CD317, HM1.24, or tetherin ) and requires Vpu s TM domain . however, the exact mechanism of how Vpu counteracts BST-2 is still unclear.
- His laboratory demonstrated that Vpu enables the optimal production and dissemination of the virus and helped shed light on the molecular and cellular mechanisms through which Vpu counteracts BST2 ( also designated Tetherin ), an interferon-regulated host factor that strongly inhibits the release and transmission of HIV-1 and other enveloped viruses.
- In the F-plasmid system the relaxase enzyme is called TraI and the relaxosome consists of TraI, TraY, TraM and the integrated host factor IHF . The nicked strand, or " T-strand ", is then unwound from the unbroken strand and transferred to the recipient cell in a 5'- terminus to 3'- terminus direction.
- Lung infections in European CF patients and neurotropic mycosis in East Asia are caused by " E . dermatitidis " strains that are genetically similar, and host factors such as immunological differences may be responsible for the different infection patterns . " Exophiala dermatitidis " occurs at very high frequency in both Asian and European saunas, and absence of neurotrophic mycosis in Europe isn't explained by reduced exposure to the fungus.
- Recent study suggested that HIV-1 prefers integration into highly spliced genes or genes with more introns . [ 2 ] This preference depends on LEDGF / p75 that was shown to interacts with many splicing factors . [ 2 ] Another study showed that HIV-1 preference for highly spliced genes depends on another host factor CPSF6, a poly adenylation factor . [ 3 ] Cancer genes were preferred by HIV-1 and this preference was due to high number of introns . [ 2]
- However, miR-122 is a promising target as it can be very selectively and effectively inhibited with antisense oligonucleotides, and as it is a conserved host factor it is hoped that the virus would not be able to acquire resistance mutations to an anti-miR-122 therapeutic . Moreover, engineering HepG2 cells to express miR-122 ( HepG2-HFL cell, HepG2 cells expressing miR-122 ) mount an effective antiviral interferon-lambda ( IFN? ) based innate immune response to hepatitis C virus ( HCV ) infection.
- The Division supports a large portfolio of investigator-initiated grants that are pursuing research focused on, but not limited to, the following areas : mechanisms of viral entry and infection, including the role of co-receptors and other cellular accessory molecules; the structure, function, and mechanism of action of viral genes and proteins; development of " in vitro " and " ex vivo " assays to monitor virus growth and immune responses against HIV, and animal models for research on the regulation and function of viral proteins and genetic regulatory sequences; the immunological and virological events controlling primary infection; factors affecting latent reservoirs of HIV; and host factors that modulate viral infection and / or disease progression.
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