kynurenine वाक्य
उदाहरण वाक्य
मोबाइल
- As a result, regulation at the kynurenine 3-monooxygenase enzyme determines the neurotoxic and neuroprotective potential of the kynurenine pathway.
- As a result, regulation at the kynurenine 3-monooxygenase enzyme determines the neurotoxic and neuroprotective potential of the kynurenine pathway.
- TDO catalyses the first and rate-limiting step of tryptophan degradation along the kynurenine pathway and thereby regulates systemic tryptophan levels.
- Docking of the kynurenine substrate into the active site suggests that Asn-333 and His-102 are involved in substrate binding.
- Kynurenine and its further breakdown products carry out diverse biological functions, including dilating blood vessels during inflammation and regulating the immune response.
- Kynurenine production is increased in Alzheimer's disease and cardiovascular disease where its metabolites are associated with cognitive deficits and depressive symptoms.
- KMO deficiency leads to an accumulation of kynurenine and to a shift within the tryptophan metabolic pathway towards kynurenine acid and anthranilic acid.
- KMO deficiency leads to an accumulation of kynurenine and to a shift within the tryptophan metabolic pathway towards kynurenine acid and anthranilic acid.
- The systematic name of this enzyme class is "'L-kynurenine : glyoxylate aminotransferase ( cyclizing ) " '.
- Kynurenine-3-monooxygenase deficiency is associated with disorders of the brain ( e . g . schizophrenia, tic disorders ) and of the liver.
- COX-2 inhibitors down-regulate indoleamine 2, 3-dioxygenase, leading to a reduction in kynurenine levels as well as reducing proinflammatory cytokine activity.
- Recent findings support the hypothesis that schizophrenia is associated with alterations of the tryptophane-kynurenine metabolic pathway due to activation of specific sections of the immune system.
- Studies have shown the beneficial effects of enzyme inhibition in these eukaryotic kynurenine 3-monooxygenase active sites, thus making this enzyme an attractive target for human drug design.
- The color change from white to yellow takes between 10 and 25 days, the reverse about six days . The yellow pigments have been identified as kynurenine and 3-hydroxykynurenine
- Evidence suggests that increased kynurenine production may precipitate depressive symptoms associated with interferon treatment for hepatitis C . Cognitive deficits in schizophrenia are associated with imbalances in the enzymes that break down kynurenine.
- Evidence suggests that increased kynurenine production may precipitate depressive symptoms associated with interferon treatment for hepatitis C . Cognitive deficits in schizophrenia are associated with imbalances in the enzymes that break down kynurenine.
- Norharmane, via inhibition of indoleamine 2, 3-dioxygenase exerts neuroprotective properties by suppressing kynurenine neurotoxic metabolites such as quinolinic acid, 3-hydroxy-kynurenine and nitric oxide synthase.
- Norharmane, via inhibition of indoleamine 2, 3-dioxygenase exerts neuroprotective properties by suppressing kynurenine neurotoxic metabolites such as quinolinic acid, 3-hydroxy-kynurenine and nitric oxide synthase.
- This mechanism involves the kynurenine pathway and the permeability transition pore; as such, targeting molecules in this pathway could prevent EndoG-mediated cell death and effectively help treat PD in patients.
- Kynurenine 3-monooxygenase regulates the downstream production of quinolinic acid, which can generate reactive free radicals and activates the NMDA subtype of glutamate receptors, producing excitotoxic lesions in the central nervous system of mammals.
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