lanosterol वाक्य
उदाहरण वाक्य
मोबाइल
- Here, the isoprene units are joined together to make squalene and then folded up and formed into a set of rings to make lanosterol.
- A number of early attempts to block the synthesis of cholesterol resulted in agents that inhibited late in the biosynthetic pathway between lanosterol and cholesterol.
- In particular, this protein catalyzes the removal of the C-14 ?-methyl group from lanosterol ( Lepesheva et al . ).
- Studies in which lanosterol synthase is partially inhibited have shown both a direct decrease in lanosterol formation and a decrease in HMG-CoA reductase activity.
- Studies in which lanosterol synthase is partially inhibited have shown both a direct decrease in lanosterol formation and a decrease in HMG-CoA reductase activity.
- Due to the enzyme s role in cholesterol biosynthesis, there is interest in lanosterol synthase inhibitors as potential cholesterol-reducing drugs, to complement existing statins.
- Disregarding some intermediate compounds ( e . g . 4-4-dimethylzymosterol ) lanosterol can be considered a precursor of zymosterol in the cholesterol synthesis pathway.
- Replacement of a hydrogen atom attached to carbon number 3 in the 5? isomer with a hydroxyl group results in lanosterol, the precursor of the steroids in animals.
- This demethylation step is regarded as the initial checkpoint in the transformation of lanosterol to other sterols that are widely used within the cell ( Lepesheva et al . ).
- It is the starting point for the synthesis of almost all plant steroids, making them chemically distinct from the steroids of fungi and animals which are instead produced from lanosterol.
- Control of the pathogen ( antifungal medication ) now relies on the application of azole fungicides which are demethylase inhibitors that inhibit lanosterol 14 alpha-demethylase ( CYP51 ) activity.
- The extra carbon in the furan ring at C-4 comes from the 3-position of mevalonic acid and represents the C-4?-methyl group of lanosterol.
- They are induced by the corticosteroid cortexolone and by phenanthrene . " C . elegans " also possesses a lanosterol 14-alpha demethylase, another enzyme in the cytochrome P450 family.
- "' Lanosterol synthase "'is an oxidosqualene cyclase ( OSC ) enzyme that converts ( S )-2, 3-oxidosqualene to a protosterol cation and finally to lanosterol.
- "' Lanosterol synthase "'is an oxidosqualene cyclase ( OSC ) enzyme that converts ( S )-2, 3-oxidosqualene to a protosterol cation and finally to lanosterol.
- In the biosynthesis of viridiol by " Gliocladium deliquescens ", the 3?-OH reduced form of viridin, the incorporation of squalene, lanosterol, dehydroxydemethoxyviridin, and demethoxyviridin was reported.
- Directed evolution and protein design have been used to identify small numbers of point mutations that alter the product specificities of OSC enzymes, most notably in altering a cycloartenol synthase to produce predominantly lanosterol.
- The enzyme-catalyzed demethylation of lanosterol is believed to occur in three steps, each of which requires one molecule of diatomic oxygen and one molecule of NADPH ( or some other reducing equivalent ).
- Miconazole, itraconazole, and clotrimazole work in a different way, inhibiting synthesis of ergosterol from lanosterol by interfering with inhibit the enzyme that performs these demethylation steps in the biosynthetic pathway between lanosterol and ergosterol.
- Miconazole, itraconazole, and clotrimazole work in a different way, inhibiting synthesis of ergosterol from lanosterol by interfering with inhibit the enzyme that performs these demethylation steps in the biosynthetic pathway between lanosterol and ergosterol.
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