megakaryocyte वाक्य
उदाहरण वाक्य
मोबाइल
- The megakaryocytes that give rise to platelets, synthesize EGF ( see this paper, as do macrophages.
- This core is surrounded by a peripheral layer of myeloid, erythroid and megakaryocyte progenitor cells and their progeny.
- Thrombopoietin, upon release, binds to its receptor, c-mpl, found on megakaryocyte progenitor cells.
- Testosterone also regulates the population of thromboxane A 2 receptors on megakaryocytes and platelets and hence platelet aggregation in humans.
- It stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets.
- PU . 1 for Erythroid-megakaryocyte lineage and GATA-1, which leads to a lymphoid-primed multipotent progenitor.
- It is expressed exclusively in megakaryocytes and platelets in humans and appears to play an important role in the formation of platelets.
- TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation.
- The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes.
- The protein encoded by this gene is a humoral growth factor necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis.
- First, P-selectin is synthesized by megakaryocytes and endothelial cells, where it is sorted into the membranes of secretory granules.
- The first KLF, KLF1, originally known as Erythroid KLF ( EKLF ) is expressed only in red blood cells and megakaryocytes.
- MiR-150 functions in hematopoiesis; it regulates genes whose downstream products encourage differentiating stem cells towards becoming megakaryocytes rather than erythrocytes.
- "' MegaCult "'is a collagen-based medium for the growth, detection and quantification of megakaryocyte progenitors.
- They are the functional equivalents of platelets, but circulate as intact mononuclear cells, and are not simply cytoplasmic fragments of bone marrow megakaryocytes.
- When megakaryocytes and endothelial cells are activated by agonists such as thrombin, P-selectin is rapidly translocated to the plasma membrane from granules.
- Thrombopoietin is bound to the surface of platelets by the mpl receptor ( CD 110 ) and destroyed, thereby reducing megakaryocyte exposure to the hormone.
- In preclinical human trials mature megakaryocytes which develop during " in vivo " treatment with Neumega were ultrastructurally, morphologically, and functionally normal.
- Thrombopoietin regulates the differentiation of megakaryocytes and platelets, but studies on the removal of the thrombopoietin receptor show that its effects on hematopoiesis are more versatile.
- Low platelets lead a higher degree of thrombopoietin exposure to the undifferentiated bone marrow cells, leading to differentiation into megakaryocytes and further maturation of these cells.
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