norethisterone वाक्य
उदाहरण वाक्य
मोबाइल
- A number of prodrugs of NET, including norethisterone acetate ( NETA ), norethisterone enanthate ( NETE ), etynodiol diacetate, lynestrenol, and quingestanol acetate, have been marketed as well.
- The drug is a relatively weak progestogen, with only about one-tenth of the progestogenic activity of norethisterone, and in relation to this fact, is no longer used in oral contraceptives.
- The discovery of the retained and potentiated progestogenic activity of 19-norsteroids like 19-norprogesterone resulted in the synthesis of norethisterone, and in turn, the introduction of the first hormonal contraceptives.
- Estradiol undecylate, in combination with norethisterone acetate ( at doses of 5 mg and 50 mg, respectively ), was studied as a combined injectable contraceptive, but ultimately was not marketed for this purpose.
- In contrast, the non-halogenated 19-nortestosterone derivatives norgestrel, norethisterone, noretynodrel, and etynodiol diacetate, which are much less potent as progestogens, did not produce such effects at the dosages tested.
- It was developed in the 1950s and, along with the testosterone derivatives ethisterone, norethisterone, normethandrone, and norethandrolone and the progesterone derivative hydroxyprogesterone acetate, was one of the first orally active progestogens to be developed.
- Treatment with a progestin, norethisterone, reduced her estradiol concentrations to normal levels and decreased the size of her ovaries and the number of ovarian cysts, alleviating her hypothalamic-pituitary-gonadal axis hyperactivity and ovarian pathology.
- Dr . Don Catlin, director of the Olympic drug-testing lab at UCLA, said that the active ingredient in most birth-control pills sold in the United States _ norethisterone _ is a close relative of nandrolone.
- In regards to the latter, estradiol valerate is available in combination with a progestogen as an combined estradiol-containing oral contraceptive ( with dienogest ) and as a combined injectable contraceptive ( with hydroxyprogesterone caproate or norethisterone enanthate ).
- However, it saw relatively little use, which was perhaps due its comparatively low potency relative to a variety of other progestins such as medroxyprogesterone acetate and norethisterone that were introduced around the same time and hence that may have been favored.
- A 2001 comparative study of the IMS LifeLink Health Plan Claims Database interpreted that in a large cohort of women using oral contraceptives, there was found a small, statistically significant increase in the risk of gallbladder disease associated with desogestrel, drospirenone and norethisterone compared with levonorgestrel.
- In addition, the testosterone analogue of 19-norprogesterone, 19-nortestosterone ( also known as nandrolone ), is an anabolic-androgenic steroid ( AAS ) and progestogen, and is the parent compound of a large group of AAS and progestins that includes norethisterone.
- However, androgenic progestins, such as 19-nortestosterone derivatives like norethisterone and levonorgestrel and others like, to a lesser extent, medroxyprogesterone acetate ( MPA ), when taken orally, induce IGF-1 production via activation of the androgen receptor ( AR ) in the liver.
- Noretynodrel, an isomer of norethisterone, was synthesized in 1952 by Frank B . Colton at Searle in Skokie, Illinois and used as the progestin in " Enovid ", marketed in the U . S . in 1957 and approved as the first oral contraceptive in 1960.
- The results of his small-scale trial ( on no more than 50 fertile married women ) led him to conclude that a dose of 3 to 4 mg of norethisterone acetate and'at least'0.05 mg of ethinylestradiol was both efficient and had few side effects.
- Alternatively, estranes such as noretynodrel and norethisterone are classified as first-generation while gonanes such as norgestrel and levonorgestrel are classified as second-generation, with less androgenic gonanes such as desogestrel, norgestimate, and gestodene classified as third-generation and newer progestins like drospirenone classified as fourth-generation.
- Among the testosterone derivatives, and in no particular order, levonorgestrel, norgestrel, norgestrienone, ethisterone, gestrinone, danazol, normethandrone, and norvinisterone have the greatest androgenic activity, while norethisterone and its prodrugs ( norethisterone acetate, norethisterone enanthate, lynestrenol, etynodiol diacetate, and quingestanol acetate ) have moderate activity.
- Among the testosterone derivatives, and in no particular order, levonorgestrel, norgestrel, norgestrienone, ethisterone, gestrinone, danazol, normethandrone, and norvinisterone have the greatest androgenic activity, while norethisterone and its prodrugs ( norethisterone acetate, norethisterone enanthate, lynestrenol, etynodiol diacetate, and quingestanol acetate ) have moderate activity.
- Among the testosterone derivatives, and in no particular order, levonorgestrel, norgestrel, norgestrienone, ethisterone, gestrinone, danazol, normethandrone, and norvinisterone have the greatest androgenic activity, while norethisterone and its prodrugs ( norethisterone acetate, norethisterone enanthate, lynestrenol, etynodiol diacetate, and quingestanol acetate ) have moderate activity.
- In terms of dosage equivalence, norethisterone and NETA are typically used at respective dosages of 0.35 mg / day and 0.6 mg / day as progestogen-only contraceptives, and at respective dosages of 0.5 1 mg / day and 1 1.5 mg / day in combination with ethinylestradiol.
norethisterone sentences in Hindi. What are the example sentences for norethisterone? norethisterone English meaning, translation, pronunciation, synonyms and example sentences are provided by Hindlish.com.