opioid antagonist वाक्य
उदाहरण वाक्य
मोबाइल
- There is some evidence that very low doses of opioid antagonists such as naltrexone reduce the severity of opioid withdrawal.
- Unlike some other opioids and opioid antagonists, buprenorphine binds only weakly to and possesses little if any activity at the sigma receptor.
- Intravenous naloxone or nalmefene, quick-acting opioid antagonists, are the first-line treatment to reverse respiratory depression caused by an overdose of opium tincture.
- On January 26, 2015, Walkinshaw introduced HB 1671, to increase access to opioid antagonists in order to reduce deaths resulting from drug overdose.
- According to a Cochrane Collaboration review, the opioid antagonist naltrexone has short-term efficacy treating alcoholism, but evidence of longer term efficacy is lacking.
- If too large a dose of the opioid antagonist is given to a dependent patient, it will result in withdrawal symptoms ( possibly severe ).
- Additionally, substitution of certain very bulky groups on carbon 6 converts naloxone into a peripherally-selective opioid antagonist with no centrally-selective antagonist properties ( naloxegol ).
- And as doctors refrain from drastic changes in dose and provide post-injection monitoring, overdoses are rare and can be quickly treated with opioid antagonists like Naloxone.
- Certain medications including opioid antagonists such as naltrexone have been shown to be effective in the treatment of alcoholism, although research has not yet demonstrated long-term efficacy.
- At high doses, it exhibits analgesic activity which is not fully reversed by opioid antagonists, suggesting that the drug has both opioid and non-opioid mechanisms of action.
- Nalorphine was the second opioid antagonist to be introduced, preceded by nalodeine ( N-allylnorcodeine ) in 1915 and followed by naloxone in 1960 and naltrexone in 1963.
- The 14-phenylpropoxy substitution appears to confer potent ?-opioid agonist activity, even when combined with substitutions such as N-cyclopropyl or N-allyl, which normally result in ?-opioid antagonist compounds.
- Some studies suggest acupuncture causes a series of events within the central nervous system, and that it is possible to inhibit acupuncture's analgesic effects with the opioid antagonist naloxone.
- Although nalbuphine possesses opioid antagonist activity, there is evidence that in nondependent patients it will not antagonize an opioid analgesic administered just before, concurrently, or just after an injection.
- Naloxone and naltrexone are commonly used opioid antagonist drugs which are competitive antagonists that bind to the opioid receptors with higher affinity than agonists but do not activate the receptors.
- Opioid antagonists such as naltrexone and nalmefene are promising potential treatments for CBD . Naltrexone and nalmefene have also shown effectiveness in the treatment of gambling addiction, an associated disorder.
- When rats are given naloxone ( an opioid antagonist ), tickling no longer evokes the 50-kHz vocalisation which indicates that the rewarding properties of tickling are modulated by endogenous opioids.
- These effects were not blocked by opioid antagonists such as naloxone, and it was eventually discovered that pravadoline represented the first compound from a novel class of cannabinoid agonists, the aminoalkylindoles.
- Surprisingly the main alkaloid from the seeds, akuammine, was found to be an opioid antagonist when tested " in vitro " and canceled out the effects of the active agonist components.
- Some opioid antagonists are not pure antagonists but in fact do produce some weak opioid partial agonist effects, and can produce analgesic effects when administered in high doses to opioid-naive individuals.
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