ouabain वाक्य
उदाहरण वाक्य
मोबाइल
- Src kinase is inhibited by-pump, while, upon ouabain binding, the Src kinase domain will be released and then activated.
- However, this possibility was excluded by the synthesis of the 11 epimer and the demonstration that it has different chromatographic behavior from ouabain.
- Research suggests that the immunoassays previously used to quantify the endogenous ouabain detected other compounds as well and this cross reactivity would have produced invalid results.
- Another argument against endogenous ouabain was the lack of effect when rostafuroxin, a drug that selectively displaces ouabain from the ATPase receptor, was administered.
- Another argument against endogenous ouabain was the lack of effect when rostafuroxin, a drug that selectively displaces ouabain from the ATPase receptor, was administered.
- At this stage Skou was unaware that ouabain inhibited the pump, but he immediately telephoned to his lab and arranged for the experiment to be done.
- At micromolar concentrations, quinidine inhibits Na + / K +-ATPase by binding to the same receptor sites as the digitalis glycosides such as ouabain.
- Plants from this genus produce toxic alkaloids and cardiac glycosides g-strophanthin ( syn . ouabain ), k-strophanthin, and e-strophanthin.
- In 1882, ouabain was first isolated from the plant by the French chemist L�on-Albert Arnaud as an amorphous substance, which he identified as a glycoside.
- Another interpretation of the analytical data led to the proposal that endogenous ouabain may have been the 11 epimer, i . e ., an isomer of plant ouabain.
- Another interpretation of the analytical data led to the proposal that endogenous ouabain may have been the 11 epimer, i . e ., an isomer of plant ouabain.
- The mechanism of selective dye uptake is incompletely understood; vital staining of nerve fibers in skin is prevented by ouabain, a drug that inhibits the Na / K-ATPase of cell membranes.
- This gene encodes a catalytic subunit of the ouabain-sensitive H + / K +-ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H + and K + ions across the plasma membrane.
- If the ion pumps are turned off by removing their energy source, or by adding an inhibitor such as ouabain, the axon can still fire hundreds of thousands of action potentials before their amplitudes begin to decay significantly.
- For instance,-- ATPase found in the membrane of heart cells is an important target of cardiac glycosides ( for example digoxin and ouabain ), inotropic drugs used to improve heart performance by increasing its force of contraction.
- Some of the chemicals in the plants are used to produce the drug Ouabain, which was taken as a cardiac stimulant to treat heart failure and sometimes g-strophanthin is advocated as an alternative treatment to more contemporary practices.
- In France and Germany, intravenous ouabain has a long history in the treatment of heart failure, and some continue to advocate its use intravenously and " per os " ( orally ) in angina pectoris and myocardial infarction.
- Post had recently discovered that three sodium ions were pumped out of the cell for every two potassium ions pumped in, and in his research he had made use of a substance called ouabain which had recently been shown to inhibit the pump.
- However, in experiments with patients where the Na + / K +-ATPase had been blocked in the underarm by infusion of the Na + / K +-ATPase-blocker Ouabain, no effect on warm-up was observed.
- Based on this scenario, NaKtide, a peptide Src inhibitor derived from-pump, was developed as a functional ouabain-- pump-mediated signal transduction .-pump also interacts with ankyrin, IP3R, PI3K, PLC-gamma and cofilin.
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