periodic paralysis वाक्य
उदाहरण वाक्य
मोबाइल
- A landmark 1990 study of a large family with a tendency toward hyperkalemic ( high-potassium ) periodic paralysis helped identify the mutation responsible.
- The channelopathies of human skeletal muscle include hyper-and hypokalemic ( high and low potassium blood concentrations ) periodic paralysis, myotonia congenita and paramyotonia congenita.
- In 1935 Mary Walker was the first to recognise the association between the condition familial periodic paralysis and hypokalaemia ( low blood potassium levels ).
- In hyperkalemic periodic paralysis, mutations occur in residues between transmembrane domains III and IV which make up the fast inactivation gate of Na v 1.4.
- In contrast, hyperkalemic periodic paralysis refers to gain-of-function mutations in sodium channels that maintain muscle depolarisation and therefore are aggravated by high potassium ion concentrations.
- Although agitation is often assumed to be a positive sign of conversion disorder, release of epinephrine is a well-demonstrated cause of paralysis from hypokalemic periodic paralysis.
- The association with the R83H mutation in KCNE3 is controversial and other groups have detected the same mutation in individuals not exhibiting symptoms of periodic paralysis.
- Patients with the rare hereditary condition of hyperkalemic periodic paralysis appear to have a heightened muscular sensitivity that is associated with transient elevation of potassium levels.
- These changes disrupt the flow of potassium ions in skeletal and cardiac muscle, leading to the periodic paralysis and irregular heart rhythm characteristic of Andersen Tawil syndrome.
- Acetazolamide ( " Acet " ) is used for treating horses with the genetic disease hyperkalemic periodic paralysis ( HYPP ), and prevents affected animals from having seizures.
- People with hypokalemic periodic paralysis are often misdiagnosed as having a conversion disorder or hysterical paralysis since the weakness is muscle-based and doesn't correspond to nerve or spinal root distributions.
- In contrast to HyperKPP, hypokalemic periodic paralysis ( noted in humans ) refers to loss-of-function mutations in channels that prevent muscle depolarisation and therefore are aggravated by low potassium ion concentrations.
- Migraines occur in up to 50 % of all hypokalemic periodic paralysis patients and may include less common symptoms like phantom smells, sensitivity to light and sound or loss of words.
- Provoking an attack with exercise and diet then trying oral potassium can be diagnostic, but also dangerous as this form of PP has an alternate form known as hyperkalemic periodic paralysis.
- Additionally, defects in both GSY1 and the SCNA4 gene, responsible for Hyperkalemic Periodic Paralysis ( HYPP ) in Quarter Horses and related breeds, has been found in 14 % of Halter horses.
- The tendency of people with hypokalemic periodic paralysis to get paralyzed when epinephrine is released in " fight or flight " situations further adds to the temptation to misdiagnose the disorder as psychiatric.
- The genes for the construction of ion channels are highly conserved amongst mammals and one condition, hyperkalemic periodic paralysis, was first identified in the descendants of Impressive, a registered Quarter Horse ( see AQHA website ).
- "' Thyrotoxic periodic paralysis "'( "'TPP "') is a condition featuring attacks of breathing muscles leads to respiratory failure, or if the low potassium levels lead to cardiac arrhythmias ( irregularities in the heart rate ).
- The symptoms of periodic paralysis can also be caused by hyperthyroidism, and are then labeled thyrotoxic periodic paralysis; however, if this is the underlying condition there are likely to be other characteristic manifestations, enabling a correct diagnosis.
- The symptoms of periodic paralysis can also be caused by hyperthyroidism, and are then labeled thyrotoxic periodic paralysis; however, if this is the underlying condition there are likely to be other characteristic manifestations, enabling a correct diagnosis.
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